OECD 405/OCSPP 870.2400: Acute eye irritation/corrosion
The OECD 405/OCSPP 870.2400 Acute Eye Irritation/Corrosion Test provides information on the health hazards of a test substance from ocular application.
Guidelines recommend in vitro or ex vivo testing prior to performing the in vivo version as this should decrease the need for in vivo testing. If an in vivo test is required, the test substance is applied into the conjunctival sac of one eye, allowing the other eye to provide a control. Ocular irritation, lesion severity and levels of reversibility are evaluated.